Lithium hydroxide, monohydrate → HCID 22638693, compound

Participants

Reaction Steps

2-(3-Cyano-1H-indol-5-ylmethyl)-cyclopropanecarboxylic acid ethyl ester (0.62 g, 2.31 mmol), methanol (10 ml), and lithium hydroxide monohydrate (0.48 g, 11.6 mmol) were heated at a gentle reflux for 2 h. The solution was concentrated in vacuo and the residue taken up in 1 N hydrochloric acid (30 ml) and extracted with ethyl acetate (3×10 ml). The combined organic extracts were dried over anhydrous sodium sulfate and concentrated in vacuo to afford 2-(3-Cyano-1H-indol-5-ylmethyl)-cyclopropanecarboxylic acid (0.45 g, 81%) as a light brown oil which solidified upon standing. LC-MS: 1.21 min; 263.2 (MNa)+.

Provenance & Evidence