Diethyl Ether → HCID 178425980, compound

Participants

Reaction Steps

2-Aminopyrimidine (0.8 g, 8.41 mmole) in dichloromethane (16 mL) at 4 C. was treated dropwise with O-mesitylenesulfonylhydroxylamine (2.65 g, 12.3 mmole) in dichloromethane (10 mL). After stirring overnight at 4 C., ether (25 mL) was added and the mixture stored at 4 C. for 3 hr. The product was filtered out and washed with 1:1 dichloromethane/ether, (50 mL) giving 2.26 g crude product. Recrystalization from methanol/dichloromethane/ether gave 2.12 g of the title compound, mp 190-191 C. Ref.: Tamura et al., J. Heterocycl. Chem. 1975;12:107.

Provenance & Evidence