Phenacyl bromide → HCID 22220747, compound

Participants

Reaction Steps

1-(2-Thiazolyl)ethyl benzoate (2.0 g, 8.5 mmole), 2-bromo-1-phenyl-1-ethanone (1.7 g, 8.5 mmole), and acetonitrile (0.4 mL) were combined and heated at 115 C. with stirring for 3 hr. After cooling, the reaction was diluted with 50 mL dichloromethane and extracted with 5×30 mL water. The combined, filtered water layers were evaporated to yield 2.2 g crude product, which crystallized from acetonitrile/ether after several days to afford 1.22 g of the title compound, mp 130-131.5 C.

Provenance & Evidence