Phenacyl bromide → HCID 86586569, compound

Participants

Reaction Steps

2-Methyl-7-oxo-5,6,7,8-tetrahydropyrimidino[4,5-d]pyrimidine (0.1 g, 0.6 mmole) and 2-bromo-1-phenyl-1-ethanone (0.12 g, 0.6 mmole) in ethanol (20 mL) were heated at reflux for 32 hr. After cooling, the precipitated hydrobromide (mp>310 C.) of the starting heterocycle was filtered out, and the filtrate was diluted with ether to form a precipitate which was recrystalized from methanol-ether to yield 47.5 mg of the title compound, mp 249-250 C.

Provenance & Evidence