2-(Phenylmethyl)pyridine → HCID 22220846, compound

Participants

Reaction Conditions

Reaction Steps

2-Benzylpyridine (1.0 g, 5.9 mmole) and 1-(bromoacetyl)pyrrolidine (1.134 g, 5.9 mmole) were heated with stirring in an oil bath at 98° C. for 2 hr. The viscous mixture was dissolved in 10 mL 4:1 acetonitrile-methanol and stored at 4° C. for 2 days. The crystals which separated were filtered out to give 1.96 g of crude product which was recrystalized from methanol-acetonitrile to give 1.45 g of the title compound, mp 224-226° C.

Provenance & Evidence