HCID 13206355, compound → HCID 178496731, compound

HRID 1836745Notes

Reaction equation

HRID 1836745 reaction equation
[CH3:1][C@H:2]([NH:12][CH3:13])[C@H:3]([O:10][CH3:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[I-].[C-:15]1(C[N+](C)(C)C)[CH:19]=[CH:18][CH:17]=[CH:16]1.[CH-:25]1[CH:29]=[CH:28][CH:27]=[CH:26]1.[Fe+2:30]>C(#N)C>[C-:15]1([CH2:13][N:12]([C@@H:2]([CH3:1])[C@H:3]([O:10][CH3:11])[C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH3:25])[CH:19]=[CH:18][CH:17]=[CH:16]1.[CH-:25]1[CH:29]=[CH:28][CH:27]=[CH:26]1.[Fe+2:30]

Participants

4

Reactant 2

HCID 13206355HCID 13206355, compoundHCID 178483341HCID 178483341, compound

Product 1

HCID 178496731HCID 178496731, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Reaction of (1R,2S)-O-methylephedrine with N-ferrocenylmethyl-N,N,N-trimethylammonium iodide (D. Lednicer and C. R. Hauser, J. Org. Chem., 40 (1960), 31) in acetonitrile gives the intermediate (−)-(1R,2S)-N-(ferrocenylmethyl)-N-methyl-1-methoxy-1-phenyl-prop-2-ylamine.

Sources & evidence

ORD record
ord-68a70c4f425f427c8f71209d647cf5f0
Source dataset
uspto-grants-2004_08
Patent number
US06777567B2

Reaction notes

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