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Sodium methanethiolate → Methyl 2-(methylthio)-4-(trifluoromethyl)benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium methanethiolate | HCID 4378561 | — |
| 反応物 | Methyl 2-chloro-4-(trifluoromethyl)benzoate | HCID 23499962 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | Methyl 2-(methylthio)-4-(trifluoromethyl)benzoate | HCID 10944828 | 94.5% |
反応手順
Dry sodium thiomethoxide (0.385 g. 0.0055M) was added to a stirred solution of methyl 2-chloro-4-trifluoromethylbenzoate (1.19 g, 0.005M) in anhydrous N-methylpyrrolidinone (10 ml) at 5° C. The mixture was acidified and extracted (t-butyl methyl ether), washed (water) and evaporated to give methyl 2-methylthio-4-trifluoromethylbenzoate (1.18 g, 94% yield). 1H-nmr 2.44(s,3H). 3.89(s,3H). 7.33(1H), 7.41(1H), 8.02(1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06777575B2 |
| 出典データセット | uspto-grants-2004_08 |
| ORD ID | ord-46dd300db15545fd944defaabf9c44cf |
| 出典メモ | uspto-grants-2004_08 |