HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2-(4-Cyclopropanecarbonyl-phenyl)-2-methylpropionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 4-(Cyclopropylcarbonyl)-alpha,alpha-dimethylbenzeneacetonitrile | HCID 23499845 | — |
| Solvent | Potassium Hydroxide | HCID 14797 | — |
| Product | 2-(4-Cyclopropanecarbonyl-phenyl)-2-methylpropionamide | HCID 23499851 | — |
Reaction Steps
Dissolve 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile (100 mg) in aqueous ethanolic potassium hydroxide (2 mL) (prepared from ethanol (5 mL), water (5 mL) and solid potassium hydroxide (1.5 g). Stir overnight at room temperature, then heat at reflux for 6 hours. Cool and evaporate the solvent in vacuo to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06777555B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-edc22b1914904cfd9e451af240482b4b |
| Source note | uspto-grants-2004_08 |