HCID 23498868, compound → HCID 23498966, compound

Participants

Reaction Steps

Horner-Emmons olefination (following the procedure of Example) of 2-formyl-3-(4-methylbenzyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene (210 mg, 0.65 mmol) followed by ester hydrolysis (following the procedure of Example) of ethyl 4-{(E)-2-[5,5,8,8-tetramethyl-3-(4-methylbenzyl)-5,6,7,8-tetrahydro-naphthalen-2-yl]vinyl}benzoate gave 4-{(E)-2-[5,5,8,8-tetramethyl-3-(4-methylbenzyl)-5,6,7,8-tetrahydro-naphthalen-2-yl]vinyl}benzoic acid (185 mg, 64%) as a white crystalline solid (m.p. 216.3-217.3° C. (CH2CL2/hexane) 42.

Provenance & Evidence