Cyclopentanone → HCID 23496719, compound

Participants

Reaction Conditions

Reaction Steps

A flask was charged with 14.6 g of magnesium and 120 ml of THF, to which a solution of 67.5 g of chloromethyltrimethylsilane diluted with 70 ml of THF was added dropwise at 50° C. The addition was followed by one hour of stirring at 65° C., after which 42.1 g of cyclopentanone was added dropwise below 20° C. After one hour of stirring at room temperature, an aqueous solution of ammonium chloride was added for hydrolysis. This was followed by ordinary post-treatments. Upon vacuum distillation, there was obtained 70.6 g (yield 82%) of 1-trimethylsilylmethylcyclopentanol.

Provenance & Evidence