Ammonia → 4-(4-(Methylsulfonyl)phenyl)-6-(trifluoromethyl)pyrimidin-2-amine
Reaction equation
CS([C:5]1[N:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][CH:12]=2)[CH:8]=[C:7]([C:21]([F:24])([F:23])[F:22])[N:6]=1)(=O)=O.[NH3:25]>C(#N)C>[CH3:20][S:17]([C:14]1[CH:15]=[CH:16][C:11]([C:9]2[CH:8]=[C:7]([C:21]([F:24])([F:23])[F:22])[N:6]=[C:5]([NH2:25])[N:10]=2)=[CH:12][CH:13]=1)(=[O:19])=[O:18]Participants
4
Procedure
A solution of 2-(methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine (2 g, 5.258 mmol) in acetonitrile (30 ml) was treated with 0.880 ammonia (6 ml) dropwise. The resulting mixture was then stirred at 20 C. for 18 h. This gave the title compound as a colourless precipitate which was collected by filtration and dried (1.53 g)
Sources & evidence
- ORD record
- ord-dcf328ae1f954ec392ac4a9836255dbb
- Source dataset
- uspto-grants-2004_08
- Patent number
- US06780870B2
Reaction notes
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