HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Cyclopentanedione → 4-[4-Fluoro-3-(2-furyl)phenyl]-1-methyl-1,2,4,6,7,8-hexahydrocyclopenta[b]pyrazolo[4,3-e]pyridine-3,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Cyclopentanedione | HCID 77466 | — |
| Reactant | 5-amino-1-methyl-2,3-dihydro-1H-pyrazol-3-one | HCID 252198 | — |
| Reactant | 4-Fluoro-3-(furan-2-yl)benzaldehyde | HCID 23497504 | — |
| Product | 4-[4-Fluoro-3-(2-furyl)phenyl]-1-methyl-1,2,4,6,7,8-hexahydrocyclopenta[b]pyrazolo[4,3-e]pyridine-3,5-dione | HCID 9947250 | 73.9% |
Reaction Steps
4-Fluoro-3-(2-furyl)-benzaldehyde (0.38 g, 2.0 mmol) from Example 14A, 1,3-cyclopentadione (0.2 g, 2.0 mmol), and 5-amino-1-methyl-1,2-dihydropyrazol-3-one (0.22 g, 2.0 mmol) were processed as described in Example 1 to provide 0.54 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06780872B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-65e4ab4fdc864a4cb049e83c1124cdb8 |
| Source note | uspto-grants-2004_08 |