3-Bromo-4-fluorobenzaldehyde → HCID 10112088, compound

Participants

Reaction Steps

2H-Pyran-3,5(4H,6H)-dione (0.11 g, 1 mmol), 3bromo-4-fluoro-benzaldehyde (0.2 g, 1 mmol), and 5-amino-1-ethyl-1,2-dihydropyrazol-3-one (0.12 g, 1 mmol) were processed as described in Example 26C to provide 0.1 g of the title compound. 1H NMR (300 MHz, DMSO-d6) δ 1.2 (t, 3H), 3.82 (q, 2H), 3.99 (s, 2H), 4.52 (q, 2H), 4.96 (s, 1H), 7.18 (m, 1H), 7.21 (t, 1H), 7.39 (dd, 1H), 9.65 (bs, 1H), 10.52 (s, 1H); MS (ESI) m/z 406 (M−H)−; Anal. calcd for C17H15N3BrFO3.0.5 C2H5OH: C, 50.13; H, 4.21; N, 9.74. Found: C, 49.94; H, 3.96; N, 9.21.

Provenance & Evidence