反应详情

温度

80 °C

The product from Example 45A (0.11 g, 1 mmol), 4-methyl-3-bromobenzaldehyde (0.2 g, 1 mmol), prepared as described in (Pearson et al., J.Org. Chem.(1958),23,1412-1416) and 2H-pyran-3,5(4H,6H)-dione (0.11 g, 1 mmol) in ethyl alcohol (2 mL) were heated at 80° C. for 2 days in a sealed tube. The reaction mixture was allowed to cool to ambient temperature and was evaporated under reduced pressure. The residue was chromatographed eluting with 19:0.5:0.5 ethylacetate:formic acid:water to provide the title compound (0.07 g).

1. temperatureto cool to ambient temperature
2. customwas evaporated under reduced pressure
3. customThe residue was chromatographed
4. washeluting with 19:0.5:0.5 ethylacetate