HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-3-nitrobenzaldehyde → 4-(4-chloro-3-nitrophenyl)-1-methyl-4,9-dihydro-1H-isoxazolo [3,4-b]pyrano[4,3-e]pyridine-3,5(6H,8H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-3-nitrobenzaldehyde | HCID 85505 | — |
| Reactant | 2H-pyran-3,5(4H,6H)-dione | HCID 325287 | — |
| Reactant | 3-Amino-2-methyl-2,5-dihydro-1,2-oxazol-5-one | HCID 23497498 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(4-chloro-3-nitrophenyl)-1-methyl-4,9-dihydro-1H-isoxazolo [3,4-b]pyrano[4,3-e]pyridine-3,5(6H,8H)-dione | HCID 10199618 | — |
Reaction Steps
The product from Example 45A (0.085 g, 0.75 mmol), 3-nitro-4-chlorobenzaldehyde(0.14 g, 0.75 mmol) and 2H-pyran-3,5(4H,6H)-dione (0.085 g, 0.75 mmol) were heated in 2 mL of ethanol for 2 days. The resulting mixture was allowed to cool to ambient temperature and filtered to provide the title compound as the filter cake (0.09 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06780872B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-2a7a9d471c4d44488addabbf1bd34d22 |
| Source note | uspto-grants-2004_08 |