2-Nitrothiophene-4-carboxaldehyde → HCID 9924484, compound

Participants

Reaction Steps

The product from Example 45A (0.086 g, 0.75 mmol), 5-nitro-3-thiophenecarbaldehyde (0.12 g, 0.75 mmol) and 2H-pyran-3,5(4H,6H)-dione (0.085 g, 0.75 mmol) in ethyl alcohol (2 mL) were heated at 80° C. for 2 days in a sealed tube. The reaction mixture was allowed to cool to ambient temperature and was evaporated under reduced pressure. The residue was crystallized from methylene chloride/ethanol to provide the title product. 1H NMR (300 MHz, DMSO-d,) δ 3.23 (s, 3H), 4.1 (q, 2H), 4.53 (s, 2H), 4.88 (s, 1H), 7.7 (d, 1H), 7.92 (d, 1H), 10.8 (s, 1H); MS (ESI) m/z 348 (M−H)−, Anal. Calcd for C14H11N3O6S: C, 48.13; H, 3.15; N, 12.03. Found: C, 47.76; H, 3.25; N, 11.78.

Provenance & Evidence