17beta-Methoxy-5beta-androstan-3-one → 3alpha-Hydroxy-17beta-methoxy-5beta-androstane

Participants

Reaction Conditions

Reaction Steps

A solution of 17β-methoxy-5β-androstan-3-one (130 mg, 0.42 mmol) in dry THF (15 mL) was treated with lithium tri(tert-butoxy)aluminum hydride (1 mL, 1M in THF, 1 mmol) at −73° C. After stirring the mixture at −75° C. for 3 hr and then at −10° C. for 1.5 hr, the mixture was quenched with NaOH solution (1N, 2 mL). The solvents were removed and the residue was extracted with EtOAc. The organic layer was washed with water, and brine. After drying over anhyd. MgSO4 the solution was filtered and evaporated to yield the crude product. This crude product was then dissolved in a small amount of CH2Cl2 and poured on a column of silica gel. Elution with toluene:acetone mixture (9:1) gave 3α-hydroxy-17β-methoxy-5β-androstane (107 mg); mp 151-156° C.; TLC Rf (hexane:acetone 7:3)=0.18.

Provenance & Evidence