HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1837135Generated: November 3, 2026
Phosphorus oxychloride → 2-Chloro-4-methyl-5-nitropyridine
https://huagongshe.com/reaction/1837135
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178429283 | HCID 178429283 | — |
| Product | 2-Chloro-4-methyl-5-nitropyridine | HCID 345364 | — |
Reaction Steps
22.3 g of 2-hydroxy-4-methyl-5-nitropyridine and 170 ml of POCl3 are mixed together and heated at 100° C. for 3 hours. The cooled reaction medium is poured onto ice to yield a beige precipitate of 2-chloro-4-methyl-5-nitropyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06780868B2 |
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| Source dataset | uspto-grants-2004_08 |
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| ORD ID | ord-b88a0ea1748b4defa6e45205de16f3c8 |
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| Source note | uspto-grants-2004_08 |
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