HCID 22390751, compound → HCID 22390789, compound

HRID 1837139Notes

Reaction equation

HRID 1837139 reaction equation
[N:1]1([S:10]([N:13]2[CH2:17][CH2:16][O:15]C2=O)(=[O:12])=[O:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1>[OH-].[Na+].C(O)C>[OH:15][CH2:16][CH2:17][NH:13][S:10]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1)(=[O:12])=[O:11]

Participants

4

Reactant 1

HCID 22390751HCID 22390751, compound

Product 1

HCID 22390789HCID 22390789, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

The product of Step 1 is dissolved in a solution of 3.2 g of sodium hydroxide in 80 ml of ethanol. After stirring for 48 hours at ambient temperature, the mixture is filtered. The filtrate is concentrated under reduced pressure, taken up in dichloromethane and washed with water. After drying and filtration, the organic phase is concentrated under reduced pressure, allowing the expected product to be obtained.

Workup

  1. filtrationthe mixture is filtered
  2. concentrationThe filtrate is concentrated under reduced pressure
  3. washwashed with water
  4. customAfter drying
  5. filtrationfiltration
  6. concentrationthe organic phase is concentrated under reduced pressure
  7. customto be obtained

Sources & evidence

ORD record
ord-a972b97b22674336831ea2940d6110f5
Source dataset
uspto-grants-2004_08
Patent number
US06780868B2

Reaction notes

Loading…