化工社化工社 化学情報印刷レポート · 研究参考用
3-Fluoro-4-methoxybenzoyl chloride → N3-(3-Fluoro-4-methoxybenzoyl)-N2-[1-(4-pyridyl)piperidin-4-ylmethyl)-2,3-pyridinediamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Fluoro-4-methoxybenzoyl chloride | HCID 2779255 | — |
| 反応物 | N2-[1-(4-pyridyl)piperidin-4-ylmethyl]-2,3-pyridinediamine | HCID 12150690 | — |
| 生成物 | N3-(3-Fluoro-4-methoxybenzoyl)-N2-[1-(4-pyridyl)piperidin-4-ylmethyl)-2,3-pyridinediamine | HCID 9932680 | 25.6% |
反応手順
Using a similar procedure to that described in Example 2, Part D, N2-[1-(4-pyridyl)piperidin-4-ylmethyl]-2,3-pyridinediamine (300 mg, 1.06 mmol) and 3-fluoro-4-methoxybenzoyl chloride (200 mg, 1.17 mmol) yielded 118 mg (15%) of the title compound as a hydrochloride salt.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06780878B2 |
| 出典データセット | uspto-grants-2004_08 |
| ORD ID | ord-ab920448bf4244398e03f67b3d991b9a |
| 出典メモ | uspto-grants-2004_08 |