2-(1-Boc-piperidin-4-ylmethylamino)-5-chloro-n-(2-pyridyl)benzamide → 5-Chloro-2-(piperidin-4-ylmethylamino)-n-(2-pyridyl)benzamide

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Reaction Steps

A solution of 2-(1-Boc-piperidin-4-ylmethylamino)-5-chloro-N-(2-pyridyl)benzamide (6.1 g, 14 mmol) in trifluoroacetic acid (125 mL) was stirred at 70° C. for 2 h, then at room temperature for 24 h. The solution was concentrated in vacuo, and the residue was directly applied to a silica gel column. Elution with dichloromethane −2 M ammonia in methanol (9:1) afforded 4.2 g (89%) of the pure title compound as a yellow solid.

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