Cyclohexanol, 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-, hydrochloride (1:1) → 2-((Dimethylamino)methyl)-1-(3-methoxyphenyl)cyclohexanol

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Tramadol hydrochloride (145 g) was dissolved in 400 mL of a 10% aqueous K2CO3 solution with magnetic stirring. The clear solution was extracted three times with ethyl acetate, dried with anhydrous Na2SO4 and evaporated to dryness on a rotovap. The oily solid was diluted with toluene and evaporated again to produce a clear oil with some white solid (110 g). The oil was filter through silica (neat) to produce a clear oil (102 g). HPLC Rt=6.794 min.

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