Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

The HCl salt was prepared as follows. To a 50 mL RBF under argon was charged with (+/−)-3-(1-Methoxy-2-methylaminomethyl-cyclohexyl)-benzonitrile (0.10 g, 0.038 mmol). To the flask was added 5 mL of dry MTBE. 2N HCl (0.38 mL, 0.76 mmol) was added dropwise at room temperature. After stirring for 1 hour at room temperature, the white precipitate was filtered in vacuo to provide 0.08 g (91%) of HCl salt. 1H NMR (CDCl3) 1.23-2.09 (m, 14H), 2.82 (m, 1H), 3.22 (s, 3H), 7.59 (m, 4H). 13C NMR (75 MHz, CDCl3) 21.4, 24.9, 26.1, 31.9, 34.1, 44.8, 50.5, 80.2, 112.9, 118.8, 129.8, 130.0, 131.1, 144.2. Mass spectrum (m/e) 260.2 (M+).

Provenance & Evidence