HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 11beta-Fluoro-7alpha-(5-hydroxypentyl)-estr4-ene-3,17-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 11beta-Fluoro-7alpha-(5-tert-butyl-dimethylsilyloxypentyl)oestr-4-ene-3,17-dione | HCID 15870660 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 11beta-Fluoro-7alpha-(5-hydroxypentyl)-estr4-ene-3,17-dione | HCID 15870661 | 115.1% |
Reaction Steps
A solution of 23.1 g of 11β-fluoro-7α-(5-tert-butyl-dimethylsilyloxypentyl)-estr-4-ene-3,17-dione in 115 ml of THF and 64 ml of water is stirred with 128 ml of glacial acetic acid for 2.5 hours at 50° C. The reaction mixture is concentrated by evaporation in a vacuum, taken up in ethyl acetate, washed with water and dried. 20.4 g of 11β-fluoro-7α-(5-hydroxypentyl)-estr-4-ene-3,17-dione is obtained as a foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06780855B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-2c70e0bc2ff54f8abf8ca4e5f9929afb |
| Source note | uspto-grants-2004_08 |