HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Iodononane → 11beta-Fluoro-3-hydroxy-7alpha-{5-[methyl-nonyl-amino]pentyl}oestra-1,3,5(10)-trien-17-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Iodononane | HCID 20275 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 11beta-Fluoro-3-hydroxy-7alpha-[5-(methylamino)-pentyl]-estra-1,3,5(10)-trien-17-one | HCID 15870665 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 11beta-Fluoro-3-hydroxy-7alpha-{5-[methyl-nonyl-amino]pentyl}oestra-1,3,5(10)-trien-17-one | HCID 69918018 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
526 mg of 11β-fluoro-3-hydroxy-7α-[5-(methyl-amino)-pentyl]-estra-1,3,5(10)-trien-17-one and 127 mg of iodononane are dissolved in 5 ml of anhydrous DMF and stirred for 4 hours at a bath temperature of 100° C. For working-up, the batch is added to semi-saturated sodium bicarbonate solution, extracted 3 times with methylene chloride, dried on magnesium sulfate and concentrated by evaporation in a vacuum. Preparative column chromatography yields 85 mg of 11β-fluoro-3-hydroxy-7α-{5-[methyl-nonyl-amino]-pentyl}-estra-1,3,5(10)-trien-17-one as a foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06780855B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-390135ea1fa541adb4ee0ec32c58faaa |
| Source note | uspto-grants-2004_08 |