Sodium Bicarbonate → 11beta-Fluoro-3-hydroxy-7alpha-{6-[methyl-(9,9,10,10,10-pentafluoro-decyl)-amino]-hexyl}-estra-1,3,5(10)-trien-17-one

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Reaction Steps

A solution of 381 mg of 11β-fluoro-3-hydroxy-7α-[6-(methyl-amino)-hexyl)-estra-1,3,5(10)-trien-17-one in 5 ml of dimethylformamide is stirred with 180 mg of 9,9,10,10,10-pentafluoro-decyltosylate for 2 hours at a bath temperature of 100° C. Then, it is added to semi-saturated sodium bicarbonate solution, extracted three times with methylene chloride, dried on magnesium sulfate, concentrated by evaporation in a vacuum and chromatographed on silica gel with dichloromethane/methanol/triethylamine. 121 mg of 11β-fluoro-3-hydroxy-7α-{6-[methyl-(9,9,10,10,10-pentafluoro-decyl)-amino]-hexyl}-estra-1,3,5(10)-trien-17-one is obtained as a foam, [α]D=+59° (c=1.0 in chloroform).

Provenance & Evidence