HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Chloride → HCID 69916466, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | N-Methyl-3-(phenylmethoxy)-1-propanamine | HCID 23497039 | — |
| Reactant | 11beta-Fluor-7alpha-(5-iodopentyl)-estra-1,3,5(10)-triene-3,17beta-diol | HCID 69918427 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 69916466 | HCID 69916466 | 44.1% |
Reaction Steps
A solution of 486 mg of 11β-fluor-7α-(5-iodopentyl)-estra-1,3,5(10)-triene-3,17β-diol in 10 ml of 1-methyl-2-pyrrolidinone is stirred with 540 mg of (3-benzyloxy-propyl)-methyl-amine for 3 hours at a bath temperature of 80° C. Then, the batch is added to saturated sodium chloride solution, extracted with ether, dried on sodium sulfate, concentrated by evaporation in a vacuum and chromatographed on silica gel with methylene chloride/methanol/ammonia. 237 mg of 7α-{5-[(3-benzyloxy-propyl)-methyl-amino]-pentyl}-11β-fluor-estra-1,3,5(10)-triene-3,17β-diol is obtained as a foam [α]D=+48° (c=0.5 in CHCl3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06780855B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-3671d13f5c5a43388e3264aa32b79b52 |
| Source note | uspto-grants-2004_08 |