HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 12150700, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | ETHYL 7-FLUORO-4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE | HCID 12150699 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 12150700 | HCID 12150700 | 96.5% |
Reaction Steps
A mixture of ethyl 7-fluoro-6-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylate (2.2 g, 8.30 mmol) and 13.2 mL of 1 N sodium hydroxide and 40 mL of ethanol is heated at reflux for 3 hours then cooled to room temperature. Water is added and the mixture is acidified with acetic acid. The resultant solid is collected by filtration washing with water to provide 1.90 g of 7-fluoro-6-methoxy-4-oxo-1,4,-dihydro-3-quinolinecarboxylic acid as a white solid, mp 265-267° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06780996B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-978fbb97423d477ab96a2319da53ab11 |
| Source note | uspto-grants-2004_08 |