2-Methoxyethanol → HCID 178496075, compound

HRID 1837341Notes

Reaction equation

HRID 1837341 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][C:18]=1F)[N:15]=[CH:14][C:13]([C:20]#[N:21])=[C:12]2[OH:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:23][O:24][CH2:25][CH2:26][OH:27]>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][C:18]=1[O:27][CH2:26][CH2:25][O:24][CH3:23])[N:15]=[CH:14][C:13]([C:20]#[N:21])=[C:12]2[OH:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 80192-MethoxyethanolHCID 178510318HCID 178510318, compound

Product 1

HCID 178496075HCID 178496075, compoundYield 86%

Procedure

Following the procedure used to prepare Reference Example 6, reaction of 6-benzyloxy-4-hydroxy-7-fluoro-3-quinolinecarbonitrile and 2-methoxyethanol provides 6-benzyloxy-4-hydroxy-7-(2-methoxyethoxy)-3-quinolinecarbonitrile in 86% yield, mp>250° C.

Workup

  1. customto prepare

Sources & evidence

ORD record
ord-783ccc5018b94224b3c8bcc06c7dd917
Source dataset
uspto-grants-2004_08
Patent number
US06780996B2

Reaction notes

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