HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Ethylpiperazin-1-YL)propan-1-OL → 4-({3-chloro-4-[(1-methyl-1H-imidazol-2-yl)sulfanyl]phenyl}amino)-7-[3-(4-ethyl-1-piperazinyl)propoxy]-6-(2-methoxyethoxy)-3-quinolinecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Ethylpiperazin-1-YL)propan-1-OL | HCID 22218516 | — |
| Reactant | 4-({3-chloro-4-[(1-methyl-1H-imidazol-2-yl)sulfanyl]phenyl}amino)-7-fluoro-6-(2-methoxyethoxy)-3-quinolinecarbonitrile | HCID 23498078 | — |
| Product | 4-({3-chloro-4-[(1-methyl-1H-imidazol-2-yl)sulfanyl]phenyl}amino)-7-[3-(4-ethyl-1-piperazinyl)propoxy]-6-(2-methoxyethoxy)-3-quinolinecarbonitrile | HCID 11764682 | 39.3% |
Reaction Steps
Following the procedure of Example 15, 4-({3-chloro-4-[(1-methyl-1H-imidazol-2-yl)sulfanyl]phenyl}amino)-7-fluoro-6-(2-methoxyethoxy)-3-quinolinecarbonitrile (300 mg, 0.62 mmol) and 1-ethyl-4-(3-hydroxypropyl)piperazine (540 mg, 3.1 mmol) provides 155 mg of 4-({3-chloro-4-[(1-methyl-1H-imidazol-2-yl)sulfanyl]phenyl}amino)-7-[3-(4-ethyl-1-piperazinyl)propoxy]-6-(2-methoxyethoxy)-3-quinolinecarbonitrile, mp 188-190° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06780996B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-fd1fcd54b4af4b3284f18d41a8e8f2d1 |
| Source note | uspto-grants-2004_08 |