反应详情

Following the procedure used to prepare Example 17, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-fluoro-3-quinolinecarbonitrile (138 mg, 0.34 mmol) and 2-methoxyethanol provides 105 mg of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-(2-methoxyethoxy)3-quinolinecarbonitrile, mp 215-217° C.