4-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-fluoro-3-quinolinecarbonitrile → 3-Quinolinecarbonitrile

HRID 1837376Notes

Reaction equation

HRID 1837376 reaction equation
ClC1C=C(Cl)C(OC)=CC=1N[C:12]1[C:21]2[C:16](=[CH:17][C:18](F)=[CH:19][CH:20]=2)[N:15]=[CH:14][C:13]=1[C:23]#[N:24]>COCCO>[N:15]1[C:16]2[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:12]=[C:13]([C:23]#[N:24])[CH:14]=1

Participants

3

Reactant 1

HCID 234980954-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-fluoro-3-quinolinecarbonitrile

Product 1

HCID 931773-Quinolinecarbonitrile

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

Following the procedure used to prepare Example 15, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-fluoro-3-quinolinecarbonitrile (300 mg, 0.83 mmol) and 2-(methoxy)ethanol provides 194 mg of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-(2-methoxy)ethoxy]-3-quinolinecarbonitrile, mp 182-183° C.

Sources & evidence

ORD record
ord-c2c8e34c8aeb4908b80196b5914ce06c
Source dataset
uspto-grants-2004_08
Patent number
US06780996B2

Reaction notes

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