反应详情

Following the procedure used to prepare Example 15, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-fluoro-3-quinolinecarbonitrile (300 mg, 0.83 mmol) and 2-(methoxy)ethanol provides 194 mg of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-(2-methoxy)ethoxy]-3-quinolinecarbonitrile, mp 182-183° C.