4-(Pyridin-3-Yloxy)Aniline → HCID 10345680, compound

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Reaction Steps

Following the procedure used to prepare Reference Example 22, a mixture of 4-chloro-6- methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinoline-3-carbonitrile (200 mg, 0.58 mmol) and 4-(pyridin-3-yloxy)phenylamine (161.5 mg, 0.87 mmol) (Cacciola, J.; Fevig, J. M.; Stouten, P. F. W.; Alexander, R. S.; Knabb, R. M.; Wexler, R. W. Bioorg. Med. Chem. Let. 2000, 10, 1253) provides 203 mg of 6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]-4-{[4-(pyridin-3-yloxy)phenyl]amino}quinoline-3-carbonitrile, mp 182-184° C.

Provenance & Evidence