Triethylamine → HCID 9809784, compound

Participants

Reaction Steps

Prepared as described in Example 2 from 2 g (3.7 mmol) of 3-[1,4′]bipiperidinyl-1′-ylmethyl-8-bromo-7-methoxy-2-phenyl-quinoline-4-carboxylic acid (compound of Description 29), 1.55 ml (11.1 mmol) of triethylamine (TEA) 1.82 g (4.8 mmol) of O-benzotriazol-1-yl-N,N,N′,N′-tetramethyluroniumhexa-fluorophosphate (HBTU) and 0.75 g (5.5 mmol) of (S)-1-phenyl-propylamine The crude material was purified by flash column chromatography on 230-400 mesh silica gel, utilising a mixture of EtOAc/MeOH 95:5 containing 0.05% NH4OH (28%) affording 0.4 g of title compound. After trituration with iPr2O, 0.3 g of the title compound were recovered as a pale yellow solid.

Provenance & Evidence