Dimethylformamide → HCID 22676969, compound

Participants

Reaction Steps

2.88 g of 3-imidazol-1-ylpropylamine and 2.33 g of triethylamine in 20 cc of dioxane were introduced into a 100 cc three-necked round-bottomed flask equipped with a magnetic stirrer, a thermometer, a dropping funnel and a condenser. 4.5 g of 7-chloro-5-methyl-3-nitropyrazolo[1,5-a]pyrimidine in solution in 20 cc of dioxane and 5 cc of dimethylformamide were added dropwise. After 2 hours of stirring at room temperature, the precipitate was filtered off. It was washed with diisopropyl ether and dried under vacuum. This gave 7.2 g of crude product. This product was taken up under reflux in 28 cc of water, then filtered off at room temperature. This operation was repeated a second time. The product was washed with ethanol and with diisopropyl ether. This gave 4.1 g of (3-imidazol-1-ylpropyl)(5-methyl-3-nitropyrazolo[1,5-a]pyrimidin-7-yl)amine in the form of a beige powder, after drying under vacuum over phosphoric anhydride, with a yield of 65%.

Provenance & Evidence