2-Chloroethanol → HCID 178428509, compound

Participants

Reaction Steps

3 g of (3-imidazol-1-ylpropyl)(5-methyl-3-nitropyrazolo[1,5-a]pyrimidin-7-yl)amine and 10 g of 2-chloroethanol were introduced into a 25 cc three-necked round-bottomed flask equipped with a magnetic stirrer, a thermometer and a condenser. The medium was refluxed for 6 hours. The reaction medium was poured into 160 cc of ethyl acetate and refluxed. The precipitate was filtered off at room temperature. This gave 3.8 g of 1-(2-hydroxyethyl)-3-[3-(5-methyl-3-nitropyrazolo[1,5-a]pyrimidin-7-ylamino)propyl]-3H-imidazol-1-ium chloride (beige powder) after drying under vacuum over phosphoric anhydride.

Provenance & Evidence