HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Peroxide → 5,6-dichloropyridine-2-carboxylic acid-N-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | 2-Pyridinecarboxylic acid, 5,6-dichloro- | HCID 13278016 | — |
| Reactant | Sodium Bisulfite | HCID 23665763 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 5,6-dichloropyridine-2-carboxylic acid-N-oxide | HCID 12993689 | — |
Reaction Steps
50% Hydrogen peroxide (38 g, 0.35 mol) was carefully added to a mechanically stirred mixture of trifluoroacetic acid (350 mL) and 5,6-dichloropyridine-2-carboxylic acid (56.4 g, 0.29 mol) at 79° C. After one hour, the reaction mixture was poured into 1 L of saturated aqueous NaHSO3, stirring vigorously and cooling in an ice bath. The precipitate was collected and dried to provide 5,6-dichloropyridine-2-carboxylic acid-N-oxide (62.9 g, 0.30 mol), mp 160° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06784137B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-13e6f9fb0c974244bd1fff3fa373763a |
| Source note | uspto-grants-2004_08 |