Potassium Carbonate → 2,3,4-Trichloro-6-(5-oxazolyl)pyridine

Participants

Reaction Conditions

Reaction Steps

A mixture of 4,5,6-trichloropyridine-2-carbaldehyde (1.66 g, 8 mmol), tosylmethyl isocyanide (1.54 g, 8 mmol) and potassium carbonate (1.09 g, 8 mmol) in methanol (20 mL) was heated at 50° C. for 30 min and then heated at 80° C. for 5 min. The solvent was removed by rotary evaporation and the residue was suspended in water (200 mL) and stirred vigorously. The precipitate was collected by suction filtration, washed with water and air-dried to provide of 2,3,4-trichloro-6-(5-oxazolyl)pyridine (1.7 g, 6.8 mmol), mp 128-130° C.

Provenance & Evidence