Methanol → HCID 12993699, compound

Participants

Reaction Steps

A solution of 4-amino-2,3-dichloro-6-(5-oxazolyl)pyridine (800 mg, 3.48 mmol), sodium acetate (571 mg, 6.96 mmol), palladium acetate (16 mg, 0.07 mmol), and 1,4-bis(diphenylphosphino)butane (30 mg, 0.07 mmol) in methanol (25 mL) was pressurized with carbon monoxide at 100 psi. After 12 hours at 100° C., the reaction mixture was cooled and concentrated. The residue was taken up into ethyl actetate and washed twice with water. The organic layer was dried (MgSO4) and concentrated to provide methyl 4-amino-3-chloro-6-(5-oxazolyl)pyridine-2-carboxylate (788 mg, 3.10 mmol), mp 166-70° C.

Provenance & Evidence