HCID 22677353, compound → HCID 178499074, compound

Participants

Reaction Steps

Methyl 4-amino-3-chloro-6-(6-t-butoxy-3-pyridinyl)pyridine-2-carboxylate (0.50 g, 1.49 mmol) was dissolved in a 1:1 mixture of THF and trifluoroacetic acid (5 mL) and heated to reflux for 30 minutes. The volatiles were removed in vacuo and the crude material was purified by HPLC (linear gradient, 100% water to 100% acetonitrile) to give of methyl 4-amino-3-chloro-6-(6-hydroxy-3-pyridinyl)pyridine-2-carboxylate (0.35 g, 1.25 mmol): Mp 251-52° C.

Provenance & Evidence