Phenyl phosphorus dichloride → HCID 22677295, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 4-amino-3-chloro-6-(6-hydroxy-3-pyridinyl)pyridine-2-carboxylate (0.30 g, 1.07 mmol) was suspended in neat dichlorophenylphosphine (2.5 mL, 1.84 mmol) and the mixture was heated to 50° C. for 1 hr. The volatiles were removed in vacuo and the residue purified by column chromatography (1:1, Hexanes/EtOAc) to give of methyl 4-amino-3-chloro-6-(6-chloro-3-pyridinyl)pyridine-2-carboxylate (0.11 g, 0.37 mmol).

Provenance & Evidence