4-Chloro-5-methylthieno[2,3-d]pyrimidine → 4-[2-Methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]-5-methylthieno[2,3-d]pyrimidine

Participants

Reaction Conditions

Reaction Steps

N-(3-amino-4-methylphenyl)-2-morpholinopyridine-4-carboxamide (0.056 g), 4-chloro-5-methylthieno[2,3-d]pyrimidine (Maybridge Chemical Company, Trevillet, Tintagel, Cornwall, PL34 0HW, GB; 0.037 g) and isopropanol (2 ml) and the reaction mixture was stirred and heated to 88° C. for 18 hours. The reaction mixture was cooled to ambient temperature and the precipitate was isolated and washed in turn with isohexane and diethyl ether. There was thus obtained the title compound (0.021 g); Mass: M+H+ 461.

Provenance & Evidence