Potassium Carbonate → HCID 22677919, compound

Participants

Reaction Steps

A mixture of 1-Boc-4-(aminomethyl)piperidine (2.0 g, 9.33 mmol), pentachloropyridine (2.58 g, 10.3 mmol) and potassium carbonate (2.58 g, 18.7 mmol) was heated at 60° C. in DMF (22 mL) for 2 h. Excess DMF was removed in vacuo and the residue taken in to water/ethyl acetate. The aqueous solution was extracted with ethyl acetate (×3) and the combined organic solution dried (MgSO4) and concentrated in vacuo. Flash chromatography (SiO2, hexane/diethyl ether 30% to 60% gave the product as a white solid (2.5 g, 62%).

Provenance & Evidence