Water → 104054-41-3

HRID 1837505Notes

Reaction equation

HRID 1837505 reaction equation
[Br:1]Br.[C:3]([CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1)(=[O:5])[CH3:4].O>CO>[Br:1][CH2:4][C:3]([CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1)=[O:5]

Participants

5

Reactant 3

HCID 962WaterHCID 24408BromineHCID 111163412-Acetylindane

Product 1

HCID 15338830104054-41-3

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10 g of pure bromine are rapidly added at 0° C. to a solution of 10 g of 2-acetylindane in 150 ml of anhydrous methanol. After one hour at ambient temperature, 100 ml of water are added and the whole is stirred for 12 hours. After extracting twice with 200 ml of diethyl ether each time, and washing the organic phase with a sodium hydrogen carbonate solution and then with water, the expected product is dried over magnesium sulphate and concentrated.

Workup

  1. extractionAfter extracting twice with 200 ml of diethyl ether each time
  2. washwashing the organic phase with a sodium hydrogen carbonate solution
  3. dry with materialwith water, the expected product is dried over magnesium sulphate
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-d2f3c070e3ad453590716dc0f62b1c51
Source dataset
uspto-grants-2004_08
Patent number
US06784183B2

Reaction notes

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