Sodium Hydroxide → HCID 178526436, compound

HRID 1837506Notes

Reaction equation

HRID 1837506 reaction equation
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH:2]1[C:10]1[N:11]=[CH:12][NH:13][CH:14]=1.[N+:15]([O-])([OH:17])=[O:16].NC(N)=O.[OH-].[Na+]>S(=O)(=O)(O)O>[N+:15]([C:6]1[CH:5]=[C:4]2[C:9](=[CH:8][CH:7]=1)[CH2:1][CH:2]([C:10]1[N:11]=[CH:12][NH:13][CH:14]=1)[CH2:3]2)([O-:17])=[O:16]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 31295Carbamimidic acid--nitric acid (1/1)HCID 178419880HCID 178419880, compound

Product 1

HCID 178526436HCID 178526436, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

5 g of 4-indan-2-yl-1H-imidazole are dissolved at 0° C. in 140 ml of pure sulphuric acid, and then 1 equivalent of urea nitrate in powder form is added in small portions. The reaction mixture is poured onto ice, rendered alkaline using sodium hydroxide solution and extracted with ethyl acetate. The expected product is obtained after evaporation.

Workup

  1. additionThe reaction mixture is poured onto ice
  2. extractionextracted with ethyl acetate

Sources & evidence

ORD record
ord-699b92fbdbb54594a794bbccc449e70a
Source dataset
uspto-grants-2004_08
Patent number
US06784183B2

Reaction notes

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