HCID 22186119, compound → HCID 22186087, compound

HRID 1837519Notes

Reaction equation

HRID 1837519 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]2[CH:12]([CH:13]=1)[C:11]([C:14]1[N:15]=[CH:16][N:17]([C:19]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:18]=1)=[CH:10][CH2:9][CH2:8]2)([O-])=O>[Pd].CO.O1CCCC1>[C:19]([N:17]1[CH:18]=[C:14]([CH:11]2[CH:12]3[CH:7]([CH:6]=[CH:5][C:4]([NH2:1])=[CH:13]3)[CH2:8][CH2:9][CH2:10]2)[N:15]=[CH:16]1)([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

4

Reactant 1

HCID 22186119HCID 22186119, compound

Product 1

HCID 22186087HCID 22186087, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21899815MeOH tetrahydrofuranSolvent

Procedure

7.7 g of the product obtained in Step 2 are stirred under a hydrogen atmosphere in the presence of 10% palladium-on-carbon in a methanol/tetrahydrofuran mixture. After filtration and concentration of the solvent, the product is used as it is in the following Step.

Workup

  1. filtrationAfter filtration and concentration of the solvent

Sources & evidence

ORD record
ord-4ddd1a82659240fc890eee0cd9a1d5b5
Source dataset
uspto-grants-2004_08
Patent number
US06784183B2

Reaction notes

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