Potassium Nitrate → 7-Nitro-2-tetralone

HRID 1837521Notes

Reaction equation

HRID 1837521 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]1=[O:11].[N+:12]([O-])([O-:14])=[O:13].[K+]>S(=O)(=O)(O)O>[N+:12]([C:8]1[CH:9]=[C:10]2[C:5]([CH2:4][CH2:3][C:2](=[O:11])[CH2:1]2)=[CH:6][CH:7]=1)([O-:14])=[O:13]

Participants

4

Reactant 2

HCID 24434Potassium NitrateHCID 682662-Tetralone

Product 1

HCID 113214437-Nitro-2-tetralone

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

At 0° C., 100 g of 2-tetralone are dissolved in 460 ml of pure sulphuric acid and 84.6 g of potassium nitrate in powder form are added in small portions. The mixture is then poured onto ice and extracted using dichloromethane. Following evaporation of the solvent, the residue is purified by chromatography on silica gel using as eluant a 90/10 cyclohexane/tetrahydrofuran mixture.

Workup

  1. additionThe mixture is then poured onto ice
  2. extractionextracted
  3. customevaporation of the solvent
  4. customthe residue is purified by chromatography on silica gel using as eluant a 90/10 cyclohexane/tetrahydrofuran mixture

Sources & evidence

ORD record
ord-4e476ae19a3e44f7adecceb60a14780c
Source dataset
uspto-grants-2004_08
Patent number
US06784183B2

Reaction notes

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