1-Bromo-4-(methylsulphonyl)benzene → HCID 22320754, compound

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Reaction Steps

Preparation of the title compound with 4-bromophenyl methyl sulphone (5.87 g, 25 mmol) and 4-pentyn-1-ol (2.1 g, 25 mmol) according to the procedure in example 18 yielded 5.12 g (87%) of yellow oil which was characterized as 5-(4-Methanesulfonylphenyl)pent-4-yn-1-ol: NMR (CDCl3) δ 1.88-1.93 (m,2H), 2.56-2.60 (t, J=6.99, 2H), 3.04 (s,3H), 3.80-3.84 (t, J=6.15,2H), 7.56 (d, J=5.1,2H), 7.85(d,J=4.8,2H). MS m/Z 239 (M+H cald. for C12H14O3S 238.3)

Provenance & Evidence