Propargyl alcohol → 3-(2-Thienyl)-2-propyn-1-ol

HRID 1837529Notes

Reaction equation

[CH2:1]([OH:4])[C:2]#[CH:3].Br[C:6]1[S:7][CH:8]=[CH:9][CH:10]=1>>[S:7]1[CH:8]=[CH:9][CH:10]=[C:6]1[C:3]#[C:2][CH2:1][OH:4]

Participants

Reactant 2

HCID 7859Propargyl alcohol

HCID 138512-Bromothiophene

Product 1

HCID 110407693-(2-Thienyl)-2-propyn-1-ol

Procedure

In a manner described in Example 18 above, propargyl alcohol was reacted with 2-bromothiophene to give the title compound as a brown oil which was used in the next step without further purification.

Sources & evidence

ORD record: ord-b86d04098f744c6db1b9508b5b9e1ee5
Source dataset: uspto-grants-2004_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06784184B2

Reaction notes

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