HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1837544Generated: October 27, 2026
Thionyl Chloride → 4-[chloro(8-quinolinyl)methyl]-N,N-diethylbenzamide
https://huagongshe.com/reaction/1837544
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | N,N-diethyl-4-[hydroxy(8-quinolinyl)methyl]benzamide | HCID 10711782 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-[chloro(8-quinolinyl)methyl]-N,N-diethylbenzamide | HCID 22677876 | — |
Reaction Steps
Compound II (2.0 g, 6.6 mmol) was dissolved in dry CH2Cl2 (25 mL) and SOCl2 (0.53 mL, 7.3 mmol) was added. The solution was stirred at 25° C. for 30 min and the solvent was evaporated in vacuo. Compound III was obtained as an oil (˜100%) and used in the next reaction without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06784181B2 |
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| Source dataset | uspto-grants-2004_08 |
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| ORD ID | ord-5f23844e816b40e9b87f1363ec549fcb |
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| Source note | uspto-grants-2004_08 |
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